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Dump-and-Bake Chicken Tzatziki Casserole – Easy, Flavorful & Family-Friendly

Make dinner effortless with this Dump-and-Bake Chicken Tzatziki Casserole! Juicy chicken, creamy tzatziki sauce, tender vegetables, and hearty grains all baked together in one dish for a simple, flavorful meal. Perfect for busy weeknights, meal prep, or feeding the whole family, this casserole is packed with Mediterranean-inspired flavors and requires minimal cleanup. A delicious, stress-free dinner everyone will love!
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Prep Time 25 minutes
Cook Time 30 minutes
Total Time 55 minutes
Course Casserole, Dinner, Family Meal, Main Course
Cuisine Comfort Food, Greek-Inspired, Mediterranean
Servings 6
Calories 350 kcal

Equipment

  • 9x13-inch baking dish or casserole pan
  • Mixing bowls for sauce and chicken
  • Knife and cutting board for vegetables
  • Spoon or spatula for layering ingredients
  • Aluminum foil for covering casserole
  • Optional: Meat thermometer

Ingredients
  

For the casserole:

  • 4 boneless, skinless chicken breasts or thighs
  • 2 cups Greek yogurt (or tzatziki)
  • 1 medium cucumber, grated and drained
  • 2–3 cloves garlic, minced or roasted
  • Juice of 1 lemon
  • 2 tbsp fresh dill, chopped
  • 1 tbsp olive oil
  • 1 bell pepper, diced
  • 1 zucchini, diced
  • 1–2 medium tomatoes, chopped
  • Salt and pepper, to taste
  • Optional: ½ cup shredded cheese (mozzarella, feta, or Parmesan)

Instructions
 

  • Preheat oven: 375°F (190°C). Pat chicken dry and season lightly with salt and pepper.
  • Prepare tzatziki sauce: Mix Greek yogurt, grated cucumber, garlic, lemon juice, dill, and a pinch of salt and pepper.
  • Chop vegetables: Dice bell pepper, zucchini, and tomatoes.
  • Layer casserole: Spread vegetables evenly in the baking dish. Place chicken on top.
  • Add sauce: Pour tzatziki mixture evenly over the chicken.
  • Add cheese (optional): Sprinkle shredded cheese on top if desired.
  • Bake: Cover with foil and bake 25–30 minutes. Remove foil during last 5–10 minutes to brown cheese.
  • Rest: Let casserole rest 5–10 minutes before serving.

Notes

  • Use thick Greek yogurt for a creamy sauce that doesn’t separate.
  • Strain cucumber to avoid watery casserole.
  • Layer vegetables evenly to ensure uniform cooking.
  • Let casserole rest to meld flavors and thicken sauce slightly.
  • Optional protein swaps: turkey, shrimp, or tofu.
  • Optional low-carb: replace starchy vegetables with cauliflower rice or skip entirely.
Keyword baked tzatziki chicken, Chicken tzatziki casserole, easy weeknight casserole, Greek chicken casserole, healthy casseroles, Mediterranean casserole